A TaqI polymorphism in the 3′UTR of the IL-12 p40 gene correlates with increased IL-12 secretion
نویسندگان
چکیده
منابع مشابه
Lack of association of IL-12 p40 gene polymorphism with peptic ulcer disease.
Interleukin 12 (IL-12) is a proinflammatory cytokine composed by two chains, p40 and p35, that plays a key role in the promotion of a Th1 immune response in the gastrointestinal mucosa. An enhanced expression of IL-12 mRNA in gastric mucosa has been reported in individuals infected by Helicobacter pylori. The aim of our study was to assess whether a functional polymorphism located at position 1...
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Combination immune checkpoint blockade has demonstrated significant clinical responses in cancers infiltrated by T cells. Many tumors contain high proportions of myeloid cells and these can secrete immunosuppressive cytokines like IL-23. Our data suggest the clinical potential of using anti-CD40 (push) and anti-IL-23 mAbs (pull) to tip the IL-12/23 balance in established tumors and act as an al...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2002
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6363919